Bacteria cause most infectious diseases. Surrounding the bacteria is the cell wall, which characteristically contains peptidoglycan in all forms of bac¬teria. Peptidoglycan is unique to prokaryotic cells which are mostly bacteria. Within the cell wall is the plasma membrane, which, like that of eukaryotic cells, consists of a phospholipid bilayer and proteins. It functions as a selectively permeable mem¬brane with specific transport mechanisms for various nutrients. However, in bacteria the plasma membrane does not contain any sterols (e.g. cholesterol), and this may alter the penetration of some chemicals.
The cell wall supports the underlying plasma mem¬brane, which is subject to an internal osmotic pressure of about 5 atmospheres in Gram-negative organisms, and about 20 atmospheres in Gram-positive organisms. The plasma membrane and cell wall together comprise the bacterial envelope.
Antibacterial medicines either hinder with theutilization of glucose, or some alternative carbon source, amino acids, nucleotides, phospholipids, amino sugars, carbohydrates and growth factors essential by the cell for survival and growth or hinder with the assembly of small molecules into macromolecules like proteins, RNA, DNA, polysaccharides and peptidoglycan.
Sulfonamides are one of the first antibiotics that came into existence after penicillin. Many sulfonamides have been developedsince, but their importance has declined in the faceof increasing resistance. The only sulfonamide drugs stillcommonly used as oralantibacterialis sulfamethoxazole(usually in combination with trimethoprim asCotrimoxazole)which is popular by the name of Generic Bactrim
Summary on Generic Bactrim
Generic Bactrim is an antibiotic medication used to treat Bacterial infections.This clinically proven medicine treats infections like diarrhea, cholera, urinary tract infection, skin infection, pneumonia and respiratory tract infection.It is a combination of two active ingredients viz. Trimethoprim and Sulfamethoxazole.It is an FDA approved drug which is safe and effective. Generic Bactrim has two main ingredients- Trimethoprim and Sulfamethoxazole in the ratio of one is to five.
Working of Generic Bactrim
Trimethoprim suppresses the activity of tetrahydrofolate and on the other hand Sulfamethoxazole attacks the microbial organism and halts its growth.These active components when combined cease bacterial growth by minimizing dihydrofolate (DHF) and its production.
Additional info on Generic Bactrim
The dose of Bactrim Generic depends upon the infection. Therefore, consult a physician before using the medication.Keep a 24 hours gap between two doses to avoid overdose. Do not crush, chew or split the medicine tablet, as it reduces drug effect.Do not use the drug if you are sensitive to any component of Generic Bactrim.Breast feeding and pregnant women should stay away from its using generic Bactrim. Avoid high fat diet, alcohol and smoking while consuming this medicine. Never give this medicine to children under the age of two. Common side effects includeNausea, Diarrhea, Drowsiness, Fever, body aches, cough and flu, Headache, Fatigue, and Pyrexia. The side effects fade in few hours, however is they persists or become serious, then seek medical care on immediate basis. No adverse effects on fertility or general reproductive performance were observed with the use of generic Bactrim.